S easonal A ffective D isorder Common Sense Pharmacologic Strategies for SA
Contents
- S easonal A ffective D isorder Common Sense Pharmacologic Strategies for SA
- Louis B. Cady, M.D. Statement of previous or current support
- "Seasonal affective disorder: a description of the syndrome & preliminary findi
- Who gets it?
- Women at increased risk for atypical depression
- Risk factors for "SAD" Depressives
- Characteristics of 467 SAD depressives in: Rosenthal NE. Diagnosis & Tx of SAD.
- Differentiation of depressive sx
- "Depression/fatigue" = exclude depression The "SSIG: E-CAPS" Acrostic [DSM
- Anxiety & Depression in Primary Care
- r/o SAD and suspect depression &/or anxiety if the patient has "Fatigue gaps" i
- Rx
- 10,000 lux most effective - Terman, et al. Efficacy of brief, intense light e
- Phototherapy side effects
- Phototherapy adjuncts
- Serotonergic pharmacotherapy: the rationale
- SAD linked to deficient brain serotonergic transmission
- Confirmatory studies
- ANTI-TREATMENT: a serotonin "Run-down" in the lab [Delgado, Charney, et al. Se
- Increase in Depression With Serotonin Depletion: Depression by the Numbers...
- More evidence: a norepinephrine "run-down" [Miller et al. "Clinical & biochemic
- RESULTS - treatment
- HAM-D Rating Scale Items found significant on analysis of variance, in AMPT tx'
- Effects of tryptophan depletion on Rx-free patients, with SAD, during stable re
- total plasma tryptophan Hamilton Depression RS
- Rx selection:
- ANTIDEPRESSANTS: The REASONABLE Primary Care Options
- Conclusions from antidepresssant drug studies:
- Doc Cady's "CAN'Ts" of TCA's...
- Rx: the old-fashioned way An Elavil cocktail - "shaken, not stirred"
- Which one to pick?
- Alcohol Analgesics Acetaminophen Aspirin Antacids Antiarrthymics Procainamide Q
- Cytochrome P-450 2D6, redux: Zoloft versus the rest
- Rational selection of antidepressant
- Depression treatment strategies
- Doc Cady's "Down-Home" Guide to Antidepressant & Anti-anxiety Therapy ...again!
- Closing thoughts...